Protein Modification Reagents
Medchemexpress LLC Bromoacetamido-PEG2-C2-NHS ester | 1353011-78-5 | 95.0% | C13H19BrN2O7 | 50 MG
Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound has a molecular weight of 395.20 and appears as a white to off-white solid-liquid mixture.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Solid-liquid mixture, white to off-white in color
Medchemexpress LLC Dspe-peg 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 500 MG
DSPE-PEG 2000 is a PEG polymer that incorporates DSPE and amine end groups. This compound can be effectively utilized for forming micelles, which are critical nanoparticles for advanced drug delivery systems.
- Forms micelles as nanoparticles
- Suitable for drug delivery applications
- Contains DSPE and amine end groups
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | MFCD13184979 | 96.2% | 657.65 | C27H36F5N3O8S | 50 MG
Biotin-PEG4-PFP ester is an activated biotin linker containing a four-unit polyethylene glycol (PEG4) spacer and a pentafluorophenyl (PFP) ester leaving group. It is designed for efficient amine coupling and biotin tagging in bioconjugation workflows such as ADC and PROTAC synthesis.
- Cleavable PEG4 spacer provides flexibility and solubility
- PFP activated ester enables rapid coupling to primary amines
- Biotin tag allows affinity capture and detection
- Suitable for antibody-drug conjugate and probe labeling workflows
- Stable as a powder at -20°C for extended storage
Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | MFCD13184955 | 98.5% | C58H108N2O29 | 10MG
Mal-amido-PEG24-acid is a maleimide-functionalized PEG24 linker with an amido-linked terminal carboxylic acid designed for assembling PROTACs and other bioconjugates. It provides a hydrophilic PEG spacer to improve solubility and a maleimide group for thiol-selective conjugation. CAS 2171095-70-6; molecular weight 1297.47 g·mol⁻1; formula C58H108N2O29.
- Maleimide group for selective thiol conjugation.
- Amido-terminated PEG24 spacer with a terminal carboxylic acid for coupling versatility.
- Hydrophilic spacer improves solubility in aqueous media.
- High purity (98.5%) suitable for research-grade bioconjugation.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC 2-(2-azidoethoxy)ethyl 4-methylbenzenesulfonate | 182347-24-6 | MFCD27946436 | 99.8% | 285.32 g·mol⁻¹ | C11H15N3O4S | 1 G
N3-PEG2-Tos is an azide-terminated PEG2 linker bearing a tosylate leaving group. It is designed as a small, bifunctional spacer for organic synthesis and bioconjugation: the azide provides a click-chemistry handle for azide-alkyne cycloadditions, while the tosylate permits nucleophilic substitution to introduce other functional groups.
- Azide functional group enables click chemistry conjugation.
- Tosylate leaving group allows facile nucleophilic substitution.
- Short PEG2 spacer provides flexibility and solubility.
- High purity suitable for synthetic and assay applications.
- Available as a 1 g solid for small-scale synthesis.
- Molecular weight ~285.3 g·mol⁻¹ for stoichiometry calculations.
Cayman Chemical Boc-NH-PEG3-CH2CoH 250mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
![eMolecules Azido-PEG2-acid | Broadpharm | 1312309-63-9 | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1687770.jpg-250.jpg)
eMolecules Azido-PEG2-acid | Broadpharm | 1312309-63-9 | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481
Azido-PEG2-acid | Broadpharm | 1312309-63-9 | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules. PROTACs, composed of two ligands linked together, target an E3 ubiquitin ligase and a specific protein, thereby utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features Alkyne group for CuAAc
- Enables selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 98.3% | 1079.16 g·mol⁻1 | C55H66N8O15 | 25 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that integrates a dibenzocyclooctyne (DBCO) click handle, a four-unit PEG spacer, and a Val-Cit protease-cleavable dipeptide with a PAB-PNP leaving group. It is designed for strain-promoted azide-alkyne conjugation and for intracellular payload release following enzymatic cleavage, supporting ADC synthesis and other bioconjugation applications.
- Enables copper-free click conjugation to azide-containing molecules.
- Four-unit PEG spacer improves solubility and reduces steric hindrance.
- Val-Cit dipeptide is cleavable by Cathepsin B for intracellular payload release.
- PAB-PNP leaving group facilitates efficient payload attachment and release.
- High purity suitable for synthetic and analytical workflows.
- Stable storage and handling conditions support reproducible conjugation.
Medchemexpress LLC NHS-PEG1-SS-PEG1-NHS | 1688598-83-5 | 98.0% | 436.41 | 50 MG
NHS-PEG1-SS-PEG1-NHS is a reversible linker designed for conjugating biomacromolecules with active small molecules.
- Reversible linker
- Designed for conjugating biomacromolecules with active small molecules
- Suitable for use in proteins
- Suitable for use in liposomes
- Suitable for use in nanoparticles
Medchemexpress LLC endo-BCN-PEG4-PFP ester | 2904607-26-5 | 95.0% | 607.56 | 100 MG
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, featuring a BCN group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a BCN group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs utilize the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-PNP | 2112738-09-5 | MFCD30828694 | >98.0% | 871.89 g/mol | C40H53N7O15 | 10 MG
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable polyethylene glycol (PEG4) antibody-drug conjugate (ADC) linker containing a maleimide thiol-reactive group, a valine-citrulline protease-cleavable dipeptide, and a para-aminobenzyl self-immolative spacer with a p-nitrophenyl leaving group. It is used in research to attach cytotoxic payloads to antibodies via thiol conjugation and enable intracellular payload release after protease-mediated cleavage.
- Cleavable val-cit dipeptide for protease-triggered payload release.
- Maleimide group for thiol-selective conjugation to cysteine residues.
- PEG4 spacer improves hydrophilicity and solubility.
- PAB self-immolative spacer enables rapid payload liberation after cleavage.
- Available in small pack sizes suitable for research-scale synthesis.
Creative Pegworks HS-PEG-SH, MW 10k - 5g
HS-PEG-SH is a linear homobifunctional PEG with two reactive free thiol. SH, sulfhydryl, or mercapto groups selectively react with maleimide and transition metal surface including gold, silver. HS-PEG-SH undergoes air oxidation and polymerization forming S-S disulfide bonds. Disulfide bond is reversible with reducing agents such as TECP. It is a useful reagent for reversible crosslinking PEGylation. HS-PEG-SH can crosslink two molecules containing maleimide. Thiol is very useful in thiol-ene reaction to react with acrylate, norbornene etc. Bifunctional thiol PEG is a common crosslinker in preparing hydrogels.
eMolecules Broadpharm / Cy5-PEG5-NHBoc / 10mg / 263744685 / BP-22349 / 96.000 / / MFCD28142459 / 881.590 / C49H73ClN4O8
Broadpharm / Cy5-PEG5-NHBoc / 10mg / 263744685 / BP-22349 / 96.000 / / MFCD28142459 / 881.590 / C49H73ClN4O8